for complete prescribing information. Store Vectical at room temperature away from moisture and heat. Do not freeze or refrigerate. Before using Vectical, tell your doctor if you have low or high levels of calcium in your blood, a calcium disorder or metabolic imbalance, or if you are receiving UV light treatments (phototherapy) for your psoriasis. Do not use in larger or smaller amounts or for longer than recommended. How should I use Vectical? Clinical Studies In two, multicenter, double-blind, vehicle-controlled studies, a total of 839 subjects with psoriasis rated "mild" or "moderate" using an investigator global assessment scale were treated twice daily for 8 weeks. Copyright Cerner Multum, Inc.
Vectical Description Vectical (calcitriol) Ointment 3 mcg/g is a vitamin D analog intended for topical application to the skin. USE IN specific populations Pregnancy Teratogenic Effects: Pregnancy Category.
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Physicians may wish to limit or avoid use of phototherapy in patients who use Vectical Ointment. The time required for UVR to induce the formation of skin tumors did not differ between animals that received plain vehicle and those that received vehicle that contained calcitriol. Based upon the recommended human dose and instructions for use, it is not possible to calculate human dose equivalents for animal exposure in these studies. Nonclinical Toxicology Carcinogenesis, Mutagenesis, Impairment of Fertility When calcitriol was applied topically to mice for up to 24 months, no significant changes in tumor incidence were observed. Wash your hands before and after applying this medicine. Concentrations of calcitriol in ointment base of 0 (vehicle control.3,.6 and.0 ppm were evaluated. Vectical Ointment is used to treat plaque psoriasis (raised, silvery flaking of the skin) in adults. The incidence of benign pheochromocytomas was significantly increased in female rats. Limitations of Use, vectical Ointment should not be applied to the eyes, lips, or facial skin. Avoid getting it on healthy skin areas. Tell your doctor about all other medicines you use, especially: other medicines to treat psoriasis; vitamin or mineral supplements that contain calcium or vitamin D; or a diuretic (water pill) such as chlorothiazide (Diuril hydrochlorothiazide (hctz, HydroDiuril, Hyzaar, Lopressor, Vasoretic, Zestoretic chlorthalidone (Hygroton, Thalitone indapamide.
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